MyBioSource.com's GNA11 antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Immunohistochemistry, and Western Blot. The GNA11 antibody was generated using GNA-11, and GNA11 as the antigen and it reacts with Human, Mouse, and Rat.
Description
Heterotrimeric guanine nucleotide-binding proteins (G proteins) consist of a, b and g subunits and mediate the effects of hormones, neurotransmitters, chemokines and sensory stimuli. To date, over 20 known Ga subunits have been classified into four families, Ga(s), Ga(i/o), Ga(q) and Ga(12), based on structural and functional similarities (1,2). Phosphorylation of Tyr356 of Ga(q)/Ga(11) is essential for activation of the G protein, since phenylalanine substitution for Tyr356 changes the interaction of Ga with receptors and abolishes ligand-induced IP3 formation (3)